Teams observed a minute of silence before the match for Jorge Messi, who died at age 68 in Argentina, where the Inter Miami captain Lionel Messi arrived on Saturday night.
“Our hearts are with our captain, Leo, and the entire Messi family,” Inter Miami said in a statement.
Argentine midfielder Rodrigo De Paul scored in the 32nd minute to give Miami a 1-0 half-time lead in the group match against the Mexican side.
Belgian striker Hugo Cuypers leveled in the 47th minute before Uruguayan striker Diego Rossi scored a 90th-minute winner.
Major League Soccer champions Miami have won their first group match 4-2 against Atletico San Luis and next face Leon on Wednesday.
